Emetic activity of reduced lysergamides.

A new efficient method for the direct amidation of d-lysergic acid was used to prepare a variety of lysergamides. A pharmacological evaluation of these compounds, their diand tetrahydro derivatives, and derivatives bearing substituents in the indole portion of the molecule showed that, in general, only 9,lOdihydrolysergamides of primary amines possess activity comparable to the potent emetic activity of the components of dihydroergotoxine.